1. to lose (money, etc.); to suffer a loss; to miss (e.g. an opportunity); to miss out (on)

2. to waste (one's time, efforts, etc.); to bring to naught; to come to nothing; to lead nowhere

3. to feel disappointed (e.g. by missing out on something); to suffer a (perceived) loss; to feel dejected (e.g. after something not going your way); to lose out (on) (oft. as 損した...)