1. to cause to go out of tune (transitive)

2. to cause to be out of shape (transitive)

3. to mess up (transitive)

4. to get sick (reflexive)

5. to get out of tune (reflexive, music)

6. to feel uneasiness or unpleasantness in the teeth and gums due to sour food, jarring noises or certain textures. (intransitive, pronominal, Mexico, Central America, Bolivia, Ecuador, Peru, Chile)